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Research Funding Impact

Since 1993, the AACR has awarded more than $540 million in grants to fund meritorious research projects across the spectrum of cancer science, including basic, translational, and clinical research. See how the AACR grants program has contributed to the AACR's mission.

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AACR grantee demonstrates the potential of PARP inhibitors in splicing factor-mutant leukemias

AACR grantee demonstrates the potential of PARP inhibitors in splicing factor-mutant leukemias

More than half of patients with myelodysplastic syndrome (MDS) have a mutation in an RNA splicing factor gene. In particular, mutations in U2AF1 and SRSF2 splicing factor genes are associated with worse overall survival and increased risk of transformation of MDS to secondary acute myelogenous leukemia. The team led by Hai Dang Nguyen, PhD, recipient of a 2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research, demonstrated the therapeutic potential of PARP inhibitors in U2AF1- and SRSF2- mutant leukemias.

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2024 AACR Annual Meeting Meet the Research Grant Reviewers Event Offers a Unique Opportunity to Interact with AACR Research Grant Reviewers 

2024 AACR Annual Meeting Meet the Research Grant Reviewers Event Offers a Unique Opportunity to Interact with AACR Research Grant Reviewers 

On Monday, April 8, 2024, attendees of the 2024 AACR Annual Meeting are invited to participate in a unique opportunity to interact with two of our research grant reviewers! This year we are thrilled to have reviewers Sandeep Burma, PhD, FNASc and Christine M. Lovly, MD, PhD answer your questions during this session. We offer you an introduction to our speakers and share what attendees can hope to gain from this event. 

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AACR Grantee Uncovers a Mechanosensitive Hormone Signaling Pathway Promoting Breast Cancer Risk

AACR Grantee Uncovers a Mechanosensitive Hormone Signaling Pathway Promoting Breast Cancer Risk

Jason Northey, PhD, recipient of the 2015 AACR Basic Cancer Research Fellowship and 2017 AACR-Janssen Fellowship in Cancer Interception Research, and his colleagues uncovered how a stiff extracellular matrix, such as that observed in high mammographic density breast tissue, promotes ERK activity, progesterone receptor-dependent RANK signaling, and increased stemness, pointing to a potential benefit of RANK signaling inhibition as an anti-cancer treatment and prevention strategy.

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AACR-Ocular Melanoma Foundation Partnership Funds Innovative Research to Combat Ocular Melanoma

AACR-Ocular Melanoma Foundation Partnership Funds Innovative Research to Combat Ocular Melanoma

Just over ten years ago, the AACR and the Ocular Melanoma Foundation (OMF) began a partnership dedicated to funding research to find a cure for ocular melanoma. Although a rare disease, uveal melanoma is the most common ocular cancer in adults with a poor long-term prognosis. The ten-year history of the AACR-OMF Grants Program is a clear example of the power of partnership in combating cancer.

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AACR Grantee Challenges a Long-Standing Belief to Uncover a Unique Population of Precancerous Cells Involved in Gastric Cancer 

AACR Grantee Challenges a Long-Standing Belief to Uncover a Unique Population of Precancerous Cells Involved in Gastric Cancer 

Valerie O’Brien, PhD, recipient of the 2018 Debbie’s Dream Foundation-AACR Gastric Cancer Research Fellowship, in memory of Sally Mandel, and her colleagues discovered a precancerous gastric epithelium cell type whose expansion is driven by the bacterium Helicobacter pylori (Hp), a bacterium that colonizes the stomach of half the world’s population.

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